The parish of Chollerton stretches from the River North Tyne to Hallington. There are wooded slopes, pasture and arable, as well as rough grassland for cattle and sheep grazing. Part of the parish boundary runs along the Roman road known as Dere Street.

A number of prehistoric stone axes, were found in Chollerton. There is also evidence of the ritual side of prehistoric life at Chollerton henge and in the cup and ring marked stones from Blue Crags hillfort and Gunnerton Crags, although neither was in its original setting.

A late 10th or 11th century Anglo-Saxon cross has been built into the walls.

Settlements changed in the Iron Age becoming more defensive and enclosed. Hillforts at Blue Crags and Oxhill Plantation used natural slopes and crags to enhance their defences and a promontory fort may have stood on Gunnerton Crags. More than ten Roman farmsteads have been discovered in the parish, many surviving as earthworks.

The Roman army built Dere Street across the parish on its way from Corbridge to the Antonine Wall. In places, the present A68 road still follows the Roman route. Roman altars found at Chollerton were probably taken from the fort at Chesters.

This North Tyne valley has been been part of the no-mans land between Scotland and England once the war with Scotland ended was affected by feuds between local Border families, known as reivers. Those who could afford it built defensive farmhouses called bastles at Colwell Demesne and Colwell to protect themselves and their livestock.

The 18th and 19th centuries brought changes in farming, with new methods and practices introduced as well as fine new farms built, such Chollerton Farm. Limestone quarries and lime kilns developed to provide agricultural lime to reduce the soil acidity at Colwell, Gunnerton Burn and Gunnerton Nick. A water mill once operated at Barrasford.

Just outside the village is an old Presbyterian Chapel, now re-furbished into extremely well appointed self catering cottages.